Sunday, September 30, 2012

Article Directory USA :: Like Nature Education Needs Changes Too

India's No.1 Portal to find the list of top and best Schools in Pune for your kids admission including admission dates, application form, admission criteria and procedure.

Pune, previously known as Punavadi and Poona is situated in the western Indian state of Maharashtra. It is also called as the ?Queen of the Deccan,? and is the cultural capital of Marathi people. Pune city is the biggest industrial town in Maharashtra. It is now a speedy growing city and is also an imperative educational centre of the western India.

Pune, being the seventh largest metropolis in India is house to many IT institutes, universities, and many other educational institutes along with top class schools which are quite in ruling mood over others. Schools have created such distinctiveness in their features that now they have been started to be addressed as unique branded schools. Students are addressed with different identity. Pune, being a the 7th metro poly in India has come up with such good numbers of Boarding schools and other such & moreover the boarding schools out here have got day boarding facilities also. The day boarding facility means students who don?t get admitted for enjoying the feeding and lodging facility both, the only they want is getting certified by such schools as the certification also matters a lot.

All such boarding schools or can be addressed as day boarding schools have got top class faculty members also who are skilled and experienced with high-caliber and the students who take admission they have also been found as intellectual and very much promising and challenging in outer world. Students are being taught with advanced technology and they are offered with many opportunities so that they can?t feel detached with other stuffs which can add feather of an extra quality to their crown.

The school facilities are such advanced learning technological devices are installed in all big schools, students are exposed to various fields of knowledge such literature, science, arts and others as well. Students are taught in such way that they can feel a package of everything, moreover now each student has been found as moving encyclopedia. Schools are too much engrossed in making each student the best for the future which is coming arrogantly towards them and they are supposed to handle it with all politeness, humbleness and furthermore with brilliancy.

This world has become too much greedy in all fields, now it needs only materialistic environment and that?s why quality matters everywhere. If you are not having your particular quality which defines your particular forte that means you are standing out of the group. Everywhere, if something is matter then it?s only crook, a mind set which always hunts for snatching the authoritative power of others, because now, it has become the protocol of this world. Nature needs changes so now this whole world is changing this way and taking a shape of world of competitive globe.

So, as schools are the initiator of the journey of one?s life towards success so first of all schools need to be changed as per the requirement of prevailing market. That?s why schools have already taken their first steps towards excellence.

Pune has got such schools also which are included in the list of initiators or pioneers.


By: Niti Sharma

This article has been written by a school guide of OnlineSchoolAdmissions.Com - a portal that provides free of cost consultancy to parents and schools for fast and easy online school admissions. Parents can locate Schools In Pune or Day Boarding Schools In Pune from the authentic list of schools and can apply to the schools of their choice online. Parents can also search for Boarding Schools In Pune according to their choice and can fill up school application forms online.

Article Directory: http://www.articledirectoryusa.com

Source: http://www.articledirectoryusa.com/article/category/reference-and-education/like-nature-education-needs-changes-too/

Article Tags: schools in pune , day boarding schools in pune , boarding schools in pune

Submitted On Sep 28, 2012. Viewed 2 times.

Source: http://www.articledirectoryusa.com/article/category/reference-and-education/like-nature-education-needs-changes-too

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New US Jobs Report Alters Presidential Campaigns (Voice Of America)

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Domestic Long Hair - Smeltser - Medium - Adult - Male - Cat | Walla ...

Domestic Long Hair - Smeltser - Medium - Adult - Male - Cat

Meet Smeltser, a one year old male cat. Smeltser came to the Humane Society as a stray whos owner never came to get him. Smeltser is ready to find his forever home, maybe with you! He is a very sweet and lovable cat who loves to take cat naps in the sun. Hurry down and come meet him today.

CHARACTERISTICS:
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Size: Medium
Petfinder ID: 24178713

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Saturday, September 29, 2012

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Google becomes online advertising king...

Gooogle has become the US market leader in online display ads, and now leads all categories for internet advertising including search and mobile, a market research firm said today. The firm eMarketer said Google will top the market for online display advertising with $US2.31 billion ($2.2 billion) in revenues -- 15.4 per cent of the market -- in 2012. Google will thus overtake Facebook in display, after the social network dethroned longtime leader Yahoo! last year, eMarketer said. The milestone means Google now holds more share than any other company in each of the US search, display and mobile advertising markets. Google will see a 38 per cent jump in online display ad revenue this year, the report said. Facebook, the consultancy said, will earn $US2.16 billion in US display ad revenues this year, up 24.4 per cent from billion last year. Facebook's share will be 14.4 per cent. Yahoo! will see nearly flat revenues for display ads, which will mean its market share will fall to 9.3 per cent this year from 11 percent last year and 14 percent in 2010. The eMarketer estimate said the overall US display ad market will grow 21.5 per cent to $US14.98 billion from $US12.33 billion in 2011, aided by mobile growth; and increased spending growth on digital video advertising, especially on Google-owned YouTube. Renner: Avengers stunts were blast'...

Jeremy Renner has raved about his time in Hollywood blockbuster Avengers Assemble - because he loved the catering. The Hurt Locker star plays Hawkeye in director Joss Whedon's action movie, which also stars Robert Downey Jr, Samuel L Jackson and Mark Ruffalo. Jeremy revealed: "Shooting the Avengers was a blast... there's much better food on set." Of the stunts and training, Jeremy admitted: "I actually didn't have to do very much archery training because I was using CGI arrows and I was shooting CGI monsters." He added: "It's like learning a new language or a dance." Co-star Tom Hiddleston, who plays villain Loki, also expressed his joy at the film's action scenes. He said: "I love doing the stunts and flying around on wires. At the very beginning, the first I had to do was jump off a platform, do a 30-foot leap and spear somebody in the chest. "Joss [Whedon] wanted me to fly beyond the horizontal, so they attached a harness to me under my costume, which enabled me to dive headfirst towards the camera. I felt like I was part of a circus trapeze act! It was fantastic." Avengers Assemble is out now on DVD.

Joss Whedon: 'The Avengers isn't a perfect movie'...

Joss Whedon has claimed that The Avengers isn't "a great movie".

The film has met with critical acclaim and outstanding commercial success, becoming the third highest-grossing film of all time in just a few months, but Whedon, the superhero blockbuster's writer and director, is determined to keep his feet on the ground.

In an interview with Vulture, the 48-year-old claimed that the box office numbers became, ultimately, "meaningless".

He said: "They're large, and you can't really count that high."

Describing what his goals were with The Avengers, he claimed: "I felt like I had a particular mission in making what I felt was a slightly old-fashioned movie, because I grew up wanting to make summer movies and wanting to make superhero movies, and I got to do both at once.

"I felt like summer movies haven't been what I remember them to be, so I felt like I would love to evoke something that's less hip and ironic and more heartfelt and character-driven, and apparently, other people cared about that in a large way."

The Buffy the Vampire Slayer and Firefly creator then conceded: "I don't think it's a perfect movie. I don't even think it's a great movie. I think it's a great time, and I'm proud of it, but for me, what was exciting is that people don't go to see a movie that many times unless it's pulling on something from within, unless there's a need there. That's very gratifying."

The film is set to increase its box office even further this weekend, after being re-released in the US to take advantage of the Labour Day holiday.

Whedon will oversee a Marvel-produced SHIELD television show for ABC, before starting work on the Avengers sequel, due for a summer 2015 release.

The Avengers Crosses $1.5 Billion At Worldwide Box Office...

While the re-release of The Avengers at the U.S. box office might have failed to break into the top ten Labor Day weekend movies, it did help The Avengers reach another major milestone. The Avengers has become the third movie in history to cross the $1.5 billion mark at the worldwide box office.

While retaining its number three position on the worldwide box office list, The Avengers took in another estimated $1.7 million over Labor Day weekend, which brought The Avengers U.S. box office total to $619.5 million and The Avengers worldwide box office total to $1.501 billion.

Interestingly enough, The Dark Knight Rises also reached a milestone today, surpassing $1 billion at the worldwide box office, which means that combined The Avengers and The Dark Knight Rises have accounted for $2.5 billion at the worldwide box office this year. If you add in The Amazing Spider-Man, which currently sits at number four on the 2012 worldwide box office list with $734.9 million, then the total rises to $3.2 billion. It?s definitely a good time to be in the superhero movie making business.

bwin.party to Be Taken Over?...

The London and Vienna-listed gambling group is said to be an acquisition target. The Austrian-British sport betting company may be taken over, the newspaper ?Guardian? says. According to rumors, there are three potential buyers. One of them is the Malaysian Genting, a second one should be an Australian betting company. The third potential buyer is a financial investor, insiders say. Bwin.party is expected to record net losses this year. In its half year report for the six months ended 30 June 2012, a solid growth in Clean EBITDA (+13%) was recorded. Losses were down from ? 41m to ? 21.3m.

Bwin.party losing its poker face...

LONDON (SHARECAST) - Online gaming titan bwin.party says revenues in the first half of 2012 grew at its casino and gaming offerings but poker has been hit by strong competitors and difficulties in southern Europe.

The group was formed last year by the merger between German outfit bwin Interactive Entertainment and British firm PartyGaming and still has co-Chief Executives Norbert Teufelberger and Jim Ryan.

On a pro forma basis (comparing the results of both companies before the merger), total revenue increased by 3% to ?410.0m (2011: ?398.0m). This was achieved despite an 11% increase in gaming taxes so that the pro forma ?clean? earnings before interest, tax, depreciation and amortisation increased 13% to ?92.3m (2011: ?81.9m). This is better than the forecast of ?89m made by analysts at Peel Hunt.

Bwin.party has also had to take a nasty one-off charge of ?31.5m after the Spanish authorities contacted all of the major online gaming operators making clear any online operator that had ever accepted customers from Spain had an obligation to pay Spanish taxes.

The group offers four online ?experiences?: sports betting produced revenues of ?128.1m in the first half, versus ?125.7m in 2011; casino and games delivered ?139.7m, against ?124.3m in the prior year; bingo was down from ?33m to ?31.5m; while the weakest performance was from poker, which fell from ?104.9m to ?96.4m.

In a joint statement, Ryan and Teufelberger said they were "determined to return [poker] to growth through execution of a detailed plan that includes pooling our poker liquidity as well as repositioning our flagship PartyPoker brand.?

The interim dividend has been increased by 10% to 1.72p per share although the company warned that net gaming revenue since June has fallen 8% as the end of the Euro 2012 Championships and a late start to the Bundesliga hit takings.

Bwin.Party Digital Entertainment: PartyCasino gets new 'Under the Sea' slot game

Check out PartyCasino via the Media Man network for more on this exciting new slot game which can be played for free or played for money. Bwin.Party is one of the most financially stable gaming companies on the planet and is listed on the London Stock Exchange. They also high security and high excitment online poker, sports betting and more.

New Trailer For Marvel Heroes...

Gazillion Entertainment is proud to show off a new trailer for Marvel Heroes. The new trailer announces 3 new playable heroes in the game ? Daredevil, Punisher, and Squirrel Girl. The trailer made its debut at the Marvel Heroes panel at PAX 2012. The panel featured Gazillion President David Brevik (one of the creators of Diablo!), legendary Marvel writer Brian Michael Bendis (Ultimate Spider-Man! Avengers vs. X-Men! And) and Marvel?s mighty VP of Games Production TQ Jefferson. If you look closely, you?ll also see a bunch of villains were also revealed in the trailer, including Mr. Fisk the notorious crime lord.

Website:
http://www.youtube.com/marvelheroesonline

About Marvel Heroes...

Marvel Heroes is a FREE-TO-PLAY action-packed massively multiplayer online game created by David Brevik, the visionary behind Diablo and Diablo 2. Set in the iconic Marvel Universe, Marvel Heroes combines the core game-play style of Diablo and MMOs with the expansive library of heroes from the Marvel Universe. In the game, players can collect and play as their favorite Marvel Superheroes (including Iron Man, Thor, Wolverine, Hulk, Spider Man, Captain America and many others). Team up with friends and try to stop Doctor Doom from devastating the world with the power of the Cosmic Cube in a story crafted by comic-book super-scribe Brian Michael Bendis.

Echo CEO Larry Mullin in shock exit as Packer target loses second key player...

Echo Entertainment has risked further antagonising its key investors with the shock decision to replace chief executive Larry Mullin in a bid to repair damaged relations with the NSW government and bring a more operational focus to the management of the embattled casino group. The board's decision agreed over the past week to replace Mr Mullin, which is understood to have also prompted the surprise resignation of long-serving director Brett Paton on Tuesday, was yesterday questioned by some of Echo's institutional investors who were taken by surprise by the decision.

Australian TV Ratings - 25th September 2012... 1. Seven News (7) 1.29 million 2. Nine News (9) 1.14 million 3. ABC News (ABC) 1.03 million 4. A Current Affair (9) 1.02 million 5. Big Brother, Nominations (9) 979,000 6. 2012 Brownlow Medal (7) 956,000 7. Today Tonight (7) 955,000 8. Big Brother, Daily Show (9) 938,000 9. Australian Story (ABC) 932,000 10. Four Corners (ABC) 847,000

Crown execs paid more despite warning - 26th September 2012

Most of Crown's senior executives received pay rises last financial year despite a rejection of the previous year's pay policy by shareholders. Casino operator Crown has made no changes to its executive pay policy despite the threat of a board spill in the event of another shareholder backlash. Four of the company's six senior executives received a larger pay package in the 2011/12 financial year, and all base salaries rose or remained the same as in 2010/11. Crown's executive pay report for the 2010/11 financial year received a 55 per cent `no' vote from Crown shareholders, and a `no' vote of at least 25 per cent against the 2011/12 report would result in the majority of board positions being vacated and put up for re-election. But Crown said in its 2011/12 annual report, released on Wednesday, it had made no change to its pay policy and had instead focused on providing a clearer explanation of its pay structure. "The Crown board remains confident that Crown's remuneration policy and the level and structure of its executive remuneration are suitable for the company and its shareholders," it said in the report. Chief executive Rowen Craigie was paid $6.875 million in the 2011/12 financial year, including a bonus of $800,000, up from $600,000 in the previous year. Mr Craigie's remuneration totalled $7.7 million in 2010/11, due to the inclusion of a $1 million benefit from the revaluation of share-based long-term incentives. His base salary remained stable at $2.98 million in 2011/12. Executive deputy chairman John Alexander's total remuneration also remained steady, at $1.5 million. Chief financial officer Ken Barton, Burswood CEO Barry Felstead, Crown Melbourne deputy CEO Greg Hawkins and executive vice president of strategy Todd Nisbet all received an increase in salary and total pay in 2011/12. Executive chairman James Packer receives no remuneration or bonuses from Crown. In the event of a board spill, Mr Packer could use his major stake in the company to effectively ensure the re-election of those board members forced to vacate their positions. Crown shareholders will vote on the report at the company's annual general meeting on October 30.

Star Casino boss Larry Mullin quits, moves back to America - 27th September 2012...

A Star casino spokesman has confirmed Mr Mullin will leave his job on January 31 ?by mutual agreement? with the board of Echo Entertainment, the parent company of The Star. He will be leaving the job almost one year to the day after the man he brought in to run the Star, Sid Vaikunta, was sacked over a sexual harassment scandal. The casino spokesman said Mr Mullin was from America and had not intended to stay in Australia forever. He denied it was linked to the Vaikunta scandal or attempts at a takeover by billionaire James Packer. Since Vaikunta quit, the board has rolled chairman John Story in favour of John O?Neill, another non-executive director Brett Paton left this week and now Mr Mullin is departing.

Brooklyn, Barclays Center bracing to steal show...

Consider Madison Square Garden on watch. Luring the Nets from New Jersey was only Step 1 in Brooklyn's metamorphosis into an entertainment hot spot. Next up for the borough, a ruthless bid in stealing the spotlight and the stars from MSG, New Jersey's Prudential Center, and any other venue that books boldface names in music and sports. There's a new kid in town, folks, a state-of-the-art arena in Brooklyn that is gobbling up acts at an alarming rate. Jay-Z, Lady Gaga, Rihanna and Andrea Bocelli are just a few of the marquee attractions coming to the new Barclays Center, a facility that will house the NBA's Brooklyn Nets and so much more. College basketball is on the way, as are the Harlem Globetrotters and World Wrestling Entertainment, and before the lockout was announced, an NHL preseason game was even on tap. Indeed, it appears Barclays has balance and boom in its acts, and will stop at nothing as it quickly makes a sudden statement that it is a desired destination in an attractive borough. And the other facilities in and around New York may never be the same again. "In the past, Brooklynites had to leave our borough for world-class entertainment and sports and head over to Manhattan, the Bronx, Queens, Nassau County ... Newark or East Rutherford," Brooklyn Borough President Marty Markowitz said. "Hello. Not anymore." Brooklyn is going hard and if this current clip keeps up, it may become the No. 1 tour stop in the region. Jay-Z, the Nets' part owner and hip-hop icon, will christen the Barclays Center with eight sold-out shows opening Friday. Holla! "Without Brooklyn, I wouldn't be standing here right now," Jay-Z said at a Barclays Center press conference. He's not alone. Barbra Streisand, a Brooklyn native like Jay-Z, will perform for the first time in her native borough Oct. 11. These megastar acts will raise the curtain on what Barclays expects to become a 220-event-a-year center, and create a little competition with the world's most famous arena. The budding Barclays-MSG bidding war, in fact, is already more heated than the Knicks-Nets rivalry. The Golden Gloves finals dumped MSG for the first time in its 86-year history for the 19,000-seat Barclays. Bocelli had played nine straight holiday shows at MSG before bolting this year for a Dec. 5 concert at Barclays. Other defections from MSG and New Jersey arenas include college basketball's Coaches vs. Cancer tournament, the Legends Classic and the Atlantic 10 tournament. But without question, none of the other facilities are intimidated by Brooklyn. This is after all, the New York market we're talking about, and there will always be plenty of acts to book. Robert Sommer, president of Rock Entertainment Management at the Prudential Center, declined comment. And MSG insists it doesn't feel threatened by the younger, hipper arena at all. "While we always respect any competition, The Garden will always be The Garden," MSG President and CEO Hank Ratner said. "Madison Square Garden is located in the heart of New York City, sitting on top of the busiest transportation hub in the nation, and has been a destination for New Yorkers and visitors to the city for over 130 years. The Garden is New York's living room, we host over 400 events annually, and are in the midst of a comprehensive, top-to-bottom transformation that has already received amazing feedback from fans." The world's most famous arena underwent an $850 million upgrade that gutted the arena from the ground up ? all without changing the building's familiar hatbox-shaped exterior. Madison Square Garden was completed in 1968 and had not had a major upgrade since 1991. And, let's not forget, the Garden is the Garden. There's no price tag, after all, on the legendary sports moments and the iconic concerts that called MSG home. Ali vs. Frazier. Willis Reed limping through the tunnel and onto the court for the 1970 NBA Finals. Mark Messier and Stephane Matteau leading the Rangers to the Stanley Cup in 1994. Billy Joel and Bruce Springsteen rocking the joint. Ricky Nelson's Garden Party. On and on. "You can bring a new venue into another borough, but you can't erase history," said Sammy Steinlight, a former MSG executive, now of Steinlight Media. "You can't just instantly have a brand. It takes time, it takes years. It takes really special and unique moments created over time." Barclays is trying to speed up the pace. Yet, not every act is choosing only one stage. The Who is booked to play Nov. 14 at Barclays, Dec. 5 at Madison Square Garden, and Dec. 6 at the five-year-old Prudential Center in Newark. While WWE remained committed to booking events at Madison Square Garden, the WWE's own Brooklyn Brawler should feel at home when the sports-entertainment promotion holds its monthly pay-per-view event Dec. 16 at Barclays. There are plenty of entertainment dollars to spread around, of course. Brooklyn's population of 2.5 million is the largest of the city's five boroughs, and is home to $3 million condominiums and four-star restaurants. The New York metropolitan area is so massive, there should be enough acts and dates for both. Barclays' honeymoon period will eventually fade. But for now, business should boom ? especially with top tickets hitting $600 for Streisand at face value. "Because the building is new, artists know the level of business they can do is higher at a brand new building," said Gary Bongiovanni, editor of the trade publication Pollstar. "The fact that it's new on the market means that the local population will turn out in great numbers, great force than you would otherwise see. That means more money in the artist's pocket." In a bustling market, the two arenas should be able to play nice. But bidding wars could spark for the top-dollar stars. The Minneapolis Target Center and the St. Paul Xcel Energy Center are separated by 10 miles from one Twin City to the other. The buildings regularly fiercely compete to land selected artists, a boon for concert promoters looking to keep down costs. "Concert promoters are certainly aware of the two buildings and they'll often bid the two buildings against each other," said Jeff Pellegrom, chief financial officer of Minnesota Sports and Entertainment, the company that runs the Xcel Center. "They'll lock or hold dates in the two different arenas and then they'll look for the best financial deal they can get. I don't blame them for this, by the way. It makes perfect sense." The Nets, the vibrant arena's anchor tenant, are focused on settling into their sparkling $1 billion digs and not the calendar of events at Madison Square Garden. "We don't concern ourselves with being better than what they do or what the Garden does," Nets general manager Billy King said. "We have a new building and we're excited about being there." So, it seems, is the rest of the entertainment industry. (MSG)

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Source: http://casinonewsmedia.blogspot.com/2012/09/casino-news-media-australia-las-vegas.html

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Cabinet Depth Refrigerators For Utility | Home improvement ...

If you ask anyone who is proud of the house they will usually tell you that one of the most important things is to be proud of is the kitchen, because the kitchen is the most important room in the house as far as they are concerned. The problem when it comes to designing the kitchen is that kitchen appliances can sometimes be strange shapes, which means they do not always fit in very easily with the overall kitchen design. The refrigerator is one of the biggest kitchen appliances there is, and it is an important one, and due to the fact that it really needs to fit in with the kitchen design many people are now opting for cabinet depth refrigerators in order to make sure the kitchen looks as good as it possibly can do. This article will take a look at some of the various types of cabinet depth refrigerator and what to do when choosing a cabinet depth fridge for a certain type of kitchen.

If you are looking for a small cabinet depth refrigerator one of the best things you can do is to go online and check out the various models that are available, because there are now so many different types you are almost certain to find one that will fit in with your kitchen style. Compact cabinet depth refrigerators can be found in many different colors and designs, and if you spend some time doing some research you?re almost certain to find one which will fit in so well beneath your present kitchen cabinets that you will hardly notice the fridge is there at all.

Of course, it is not only a case of finding a cabinet depth fridge which fits in with the cabinets and makes the kitchen look good, because there is also the important factor of the utility of the fridge to bear in mind. If you are looking for something that has a lot of storage capacity, you need to make sure you have plenty of refrigerator shelves. There are now many different types of three and four shelf cabinet depth refrigerator models which will enable you to store food easily. It is usually a good idea to look at refrigerators with adjustable shelves, as this makes the storage far more useful. There is also the question of a temperature gauge, or even better a digital temperature monitor, to make sure that the temperature of the refrigerator stays within the normal level.

In terms of brands of cabinet depth fridges, you could look at GE cabinet depth refrigerators, as the supplier has quite a few models on the market and you are sure to find one to suit your needs. However, Whirlpool cabinet depth refrigerators are also a popular choice, since there are quite a few large cabinet depth refrigerator models from this company, which can give a refrigeration capacity of up to 20 cu ft or more. If you are looking for a wide cabinet depth refrigerator make sure you look at two door counter depth refrigerator models, because these will enable you to get into the refrigerator much more easy.

There is a good choice of different models which, as well as having adjustable shelves, also have various refrigeration compartments for different foodstuffs. For many people it can be absolutely essential that there is a vegetable compartment, and also a vegetable crisper, which can be essential for some types of vegetables and fruits in order to keep the food in the right state. Something to bear in mind is also whether you want the cabinet depth fridge to be portable, and if this is the case you need to look at the model that has castors rather than feet.

There is also the consideration of whether or not you want a separate ice making compartment, something which is important if you want to have cold drinks. A wine chiller as part of the cabinet depth fridge could also be a consideration worth bearing in mind, as could be a compartment to keep beer cold. There are many types of small width refrigerators nowadays, including compact cabinet depth models which are made for a small kitchen. A cabinet depth refrigerator suitable for a small kitchen is something that is really worth looking into because it can make for far more space within the kitchen itself, something which is important if you do not have the space for a tall refrigerator.

Think as well about the type of doors you want on the cabinet depth refrigerator, because some people prefer French door models, while others prefer sliding door cabinet depth refrigerators, since these allow for easy access and also mean that you do not have to use up too much space. Take time to look at the various models that are available and make sure you also look at the various functions of the refrigerator before making your final purchase decision.

Source: http://www.gradcmu.net/cabinet-depth-refrigerators-for-utility

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GSAT-10, Indias heaviest communication satellite launced ...

GSAT-10, Indias heaviest communication satellite launced successfullyBangalore: India?s advanced communication satellite GSAT-10 that is expected to augment telecommunication, direct-to-home broadcasting and radio navigation services was successfully launched early today on board Ariane-5 rocket from Europe?s spaceport in French Guiana in South America.

At the end of a smooth countdown lasting 11 hours and 30 minutes, Ariane-5 ECA rocket injected GSAT-10 into an elliptical Geosynchronous Transfer Orbit (GTO), very close to the intended one, after a flight of 30 minutes and 45 seconds, Indian Space Research Organisation said.

At 3,400 kg at lift-off, GSAT-10 is the heaviest built by Bangalore-headquartered ISRO.GSAT-10 project is a Rs 750 crore mission that includes the cost of satellite, launch services by the European space consortium Arianespace and insurance.

Soon after GSAT-10 was hurtled into space, ISRO?s Master Control Facility (MCF) at Hassan in Karnataka took over the command and control of the satellite and declared the launch of Indian space agency?s 101st space mission a success.

?The satellite is in good health?, ISRO said after checks on various subsystems of the spacecraft, adding all its parameters were satisfactory.

Blasting off from the launch pad at 2.48 am (IST), Arianespace?s rocket first injected European co-passenger ASTRA 2F into orbit followed by GSAT-10. With a 15-year design life, GSAT-10 is expected to be operational by November and will augment telecommunication, DTH and radio navigation services by adding 30 more to the much-in-demand transponder capacity, now hit by a crunch.

ISRO Chairman K Radhakrishnan, who was at MCF at Hassan at the launch, said, ?By November 2012, we expect to operationalise GSAT-10 and make it available to the user community.

GSAT-10 is fitted with 30 transponders (12 Ku-band, 12 C-band and six Extended C-Band), which will provide vital augmentation to INSAT/GSAT transponder capacity.

With a scramble for transponders, India is now managing a significant part of its requirement by leasing foreign transponders to meet the domestic demand.

GSAT-10 also has a navigation payload ? GAGAN (GPS aided Geo Augmented Navigation) ? that would provide improved accuracy of GPS signals (of better than seven metres) to be used by Airports Authority of India for civil aviation requirements.

This is the second satellite in INSAT/GSAT constellation with GAGAN payload after GSAT-8, launched in May 2011.

GSAT-10 was originally scheduled for a 22 September launch, but was deferred after scientists detected a small glitch ? one gram of dust ? in the upper part of the rocket.

GSAT-10 Project Director TK Anuradha, Additional Secretary of Department of Space, S Srinivasan and Director of ISRO Satellite Centre SK Shivakumar were among key ISRO officials who were in French Guiana for the launch.

Shivakumar said GSAT-10 would give an impetus to the ?communication revolution? in India.

In the coming five days, orbit raising manoeuvres will be performed to place the satellite in the Geostationary Orbit with required inclination with reference to the equator, ISRO said.

The satellite will be moved to the Geostationary Orbit (36,000 km above the equator) by using the satellite propulsion system in a three step approach. After the completion of orbit raising operations, the two solar panels and both the dual gridded antenna reflectors of GSAT-10 will be deployed for further tests and operations.

It is planned to experimentally turn on the communication payloads in the second week of October, ISRO said.

After the successful completion of all in-orbit tests, GSAT-10 will be ready for operational use by November. GSAT-10 will be positioned at 83 deg East orbital location along with INSAT-4A and GSAT-12.

PTI



Source: http://www.west-bengal.com/india/gsat-10-indias-heaviest-communication-satellite-launced-successfully/175955.html

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Friday, September 28, 2012

Lawsuit: Pentagon denied rape victims their rights

By Jeff Black, NBC News

Nineteen veterans and active-duty service members from the Army and Air Force allege in a new lawsuit filed Friday that they were sexually assaulted while in the military and Defense Secretary Leon Panetta and other leaders denied them their constitutional rights of due process after reporting the crimes.

The suit seeks monetary damages, though no precise figure was named. It is the fifth lawsuit of its kind filed by Susan Burke, a Washington, D.C.-based attorney.


The 15 women and four men named in the suit were all retaliated against after reporting rapes and were denied the right to have their cases heard by an impartial party, Burke said. In the military, senior commanders are in charge of determining whether reported sexual assaults will be referred to military courts.

Related:?Victims of sexual assault in military say brass often ignore pleas for justice

?Anyone who has looked closely at these types of cases knows that we have a disgraceful system,? Burke told NBC News. ?It is controlled by the chain of command. These rape survivors were all denied entry into a court system, and they were retaliated against.?

While each case has different facts on the time and place of the assault, they demonstrate a pattern of a systematic failure of leadership and oversight, Burke said, explaining why Panetta is named in the suit.

The lawsuit filed Friday comes on the heels of a rare case of an Army general being charged with sexual assault and a scandal at Lackland Air Base in San Antonio, Texas, in which at least in which at least a dozen military instructors are accused of sexually assaulting young female recruits.

Related:?Army general accused of sex misconduct

Army Brig. Gen. Jeffrey A. Sinclair, who has served 27 years, including tours of Afghanistan and Iraq, on Wednesday was charged with forced sex on a subordinate and other offenses. He was relieved of his duty in May and recalled to Fort Bragg, N.C., where the charges were referred to military investigators.

Rep. Jackie Speier, D-Calif., joined a news conference in San Francisco announcing the new lawsuit.

Watch US News videos on NBCNews.com?

In November 2011, Speier introduced legislation in Congress to reform the military justice system and the way it handles cases of rape and sexual assault. H.R. 3435, the Sexual Assault Training and Oversight Prevention Act (STOP Act), would create an impartial office made up of civilian and military experts within the military to review cases of rape and sexual assault. The bill has 133 bipartisan cosponsors.

For his part, Panetta has moved to change how sexual assaults are reported and dealt with inside the armed forces. In April, he issued new policies requiring that more senior commanders handle sexual assault complaints. And on Tuesday he ordered all military branches to improve the quality of sexual assault prevention and training.

However, Burke, and activists claim those moves fall short.

"This has been going on for years," Burke said. "Clearly, keeping these cases inside the military system isn't working." ??

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Source: http://usnews.nbcnews.com/_news/2012/09/28/14127398-lawsuit-pentagon-denied-rape-victims-their-constitutional-rights?lite

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Study reveals wide discrepancy in multidrug surveillance among intensive care units

Study reveals wide discrepancy in multidrug surveillance among intensive care units [ Back to EurekAlert! ] Public release date: 28-Sep-2012
[ | E-mail | Share Share ]

Contact: Liz Garman
egarman@apic.org
202-454-2604
Elsevier Health Sciences

Washington, DC, September 28, 2012 Screening practices for multidrug-resistant organisms (MDROs) in intensive care units (ICUs) vary widely from hospital to hospital, according to a new study published in the October issue of the American Journal of Infection Control, the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC).

The P-NICE interdisciplinary research team from the Columbia University School of Nursing collected and analyzed survey responses from the infection preventionists (IPs) of 250 hospitals that participated in the Centers for Disease Control and Prevention's (CDC's) National Healthcare Safety Network (NHSN) in 2008. The goal of the study was to explore the relationship between hospital and infection control characteristics and the adoption, monitoring, and implementation of infection control policies aimed at MDROs.

Researchers found that participating NHSN ICUs routinely screened for methicillin-resistant Staphylococcus aureas (59 percent). However, other potentially deadly MDROs were screened for far less frequently: vancomycin-resistant Enterococcus (22 percent), gram-negative rods (12 percent), and C. difficile (11 percent).

Forty percent of ICUs reported a written policy to screen for any MDRO, and less than one-third (27 percent) had a policy for periodic screening following admission. One-third reported a policy requiring isolation/contact precautions pending screening, 98 percent reported requiring contact precautions for culture-positive patients, and 42 percent reported a policy for grouping colonized patients together.

The study found that state-mandated reporting, being a teaching hospital, having 201-500 beds, and being located in the western United States were factors associated with having a policy to screen all admissions for any MDRO. Periodic screening after admission was correlated with mandated reporting, teaching status, and use of an electronic surveillance system.

"There is significant variation in adoption of screening and infection control interventions aimed at MDRO and C. difficile in NHSN ICUs, which is congruent with data from other studies and may reflect wide variation in published recommendations or their interpretation," said Monika Pogorzelska, PhD, MPH, lead study author. "Additionally, with the current increase in mandatory reporting, IPs may be focusing on fulfilling mandates rather than implementing policies based on their experience and hospital needs. Further research is needed to provide additional insight on effective strategies and how best to promote compliance."

"Rather than being driven by legislative mandates that are not evidence based, MDRO screening should be based on a facility's risk assessment, as the epidemiology of these organisms can vary from region to region," said APIC 2012 President Michelle Farber, RN, CIC. "APIC recommends that each institution designs an HAI prevention program that is effective for their facility and needs."

###



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Study reveals wide discrepancy in multidrug surveillance among intensive care units [ Back to EurekAlert! ] Public release date: 28-Sep-2012
[ | E-mail | Share Share ]

Contact: Liz Garman
egarman@apic.org
202-454-2604
Elsevier Health Sciences

Washington, DC, September 28, 2012 Screening practices for multidrug-resistant organisms (MDROs) in intensive care units (ICUs) vary widely from hospital to hospital, according to a new study published in the October issue of the American Journal of Infection Control, the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC).

The P-NICE interdisciplinary research team from the Columbia University School of Nursing collected and analyzed survey responses from the infection preventionists (IPs) of 250 hospitals that participated in the Centers for Disease Control and Prevention's (CDC's) National Healthcare Safety Network (NHSN) in 2008. The goal of the study was to explore the relationship between hospital and infection control characteristics and the adoption, monitoring, and implementation of infection control policies aimed at MDROs.

Researchers found that participating NHSN ICUs routinely screened for methicillin-resistant Staphylococcus aureas (59 percent). However, other potentially deadly MDROs were screened for far less frequently: vancomycin-resistant Enterococcus (22 percent), gram-negative rods (12 percent), and C. difficile (11 percent).

Forty percent of ICUs reported a written policy to screen for any MDRO, and less than one-third (27 percent) had a policy for periodic screening following admission. One-third reported a policy requiring isolation/contact precautions pending screening, 98 percent reported requiring contact precautions for culture-positive patients, and 42 percent reported a policy for grouping colonized patients together.

The study found that state-mandated reporting, being a teaching hospital, having 201-500 beds, and being located in the western United States were factors associated with having a policy to screen all admissions for any MDRO. Periodic screening after admission was correlated with mandated reporting, teaching status, and use of an electronic surveillance system.

"There is significant variation in adoption of screening and infection control interventions aimed at MDRO and C. difficile in NHSN ICUs, which is congruent with data from other studies and may reflect wide variation in published recommendations or their interpretation," said Monika Pogorzelska, PhD, MPH, lead study author. "Additionally, with the current increase in mandatory reporting, IPs may be focusing on fulfilling mandates rather than implementing policies based on their experience and hospital needs. Further research is needed to provide additional insight on effective strategies and how best to promote compliance."

"Rather than being driven by legislative mandates that are not evidence based, MDRO screening should be based on a facility's risk assessment, as the epidemiology of these organisms can vary from region to region," said APIC 2012 President Michelle Farber, RN, CIC. "APIC recommends that each institution designs an HAI prevention program that is effective for their facility and needs."

###



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-09/ehs-srw092812.php

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VOLLEYBALL: Eastern Loses Heartbreaker to Southern Utah - SWX ...

by EWU Athletics

In the first-ever Big Sky matchup between the Eastern Washington University volleyball team and the Thunderbirds of Southern Utah, the Eagles were handed a tough 3-2 loss on their home court in Cheney, Wash. Despite a dominating performance in the second and third sets, Eastern could not hold on, as it dropped its 16th-consecutive match and fifth in the league season, 25-18, 16-25, 17-25, 25-22, 15-11.

With the win, Southern Utah improves to 7-9 overall and 3-2 in Big Sky play. Still searching for that elusive first win, Eastern will take on Northern Arizona on Friday (Sept. 28) at Reese Court starting at 7 p.m.

The Eagles committed 10 offensive errors in the first set, leading to a 25-18 loss. But after dropping the opener on their home floor, the Eagles responded with a vengeance. Eastern had 30 kills with just seven errors in the second and third sets for a combined .311 attack percentage. Eastern's defensive was equally sharp, holding the Thunderbirds to just .109 hitting.

Eastern had the momentum on its side heading into the fourth set, but Southern Utah scored a quick two points to start it off, which shifted the energy in Reese Court just slightly. The Eagles continued to fight and kept it close the entire way. There were 11 ties and six lead changes in the set, but SUU used a late 6-2 run to eventually capture it, 25-22.

In the decisive fifth, Eastern dug itself into a dangerous 6-1 hole. But a timely service error by SUU sparked a 6-1 run for the Eagles, and they managed to tie it up at 7-7. Following a timeout called by Southern Utah, the Thunderbirds blocked five of the next six EWU attack attempts to take an irrevocable 14-8 lead. Senior Cora Kellerman saved three match points for her team with two kills and a solo block, but SUU put it away with a kill by senior Cashaana Renfro.

"We just got timid," said EWU head coach Lisa Westlake. "We need to be tougher in these situations. We were up 2-1 after the third set, but then they started serving harder and we eased up on ours. Then our passing started to go as well. It was great to see us compete, but we need to finish."

Eastern was led by sophomore Kelsey Julian (Kennewick, Wash.), who finished with a career-high 13 kills on a sizzling .550 attack percentage. She also had five digs, two blocks and an ace for the Eags.

"Kelsey did a phenomenal job," commended Westlake. "She has been competing hard in practice, and her numbers have just been improving and improving. We gave her a chance tonight, and she went in there and took care of business."

Freshman Allie Schumacher (Puyallup, Wash.) also tallied a career high 13 kills, and had six digs as a starter. Kellerman (La Conner, Wash.) registered her fourth double-double of the season with 12 kills and 12 digs.

Senior setter Laney Brown (Waterville, Wash.) finished the night with 50 assists - just two shy of her career-high set back in 2010. She also had eight digs and two kills. Junior Celeste Crosby (Spokane, Wash.) suited up as libero for EWU, and picked up a career-high 22 digs.

Eastern's middle blockers, Talia Fermantez and Kellen Barfield, combined for 20 kills and seven blocks.

As a team, EWU tallied eight total blocks, but the Thunderbirds put up an impressive 17. SUU's Renfro finished with 11 - the best blocking performance by any player in the Big Sky this season. Senior Ana Mailoto, currently the No. 1 hitter in league-only statistics, had 25 kills and 16 digs for SUU.

Source: http://www.swxrightnow.com/story/19668316/volleyball-eastern-loses-heartbreaker-to-southern-utah

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Thursday, September 27, 2012

Photos: The AK-47 assault rifle ... as art

The exhibition, 'AKA Peace,' in collaboration with non-profit organization Peace One Day, showcases artists reinterpretation of AK-47 assault rifles, reacting against the horror of violence globally and recasting a weapon of devastation as a conduit to peace. Currently on display at the Institute of Contemporary Arts in London, the art installations are to be auctioned after the exhibition on Oct. 4 to raise funds for Peace One Day.

Source: http://news.yahoo.com/photos/artists-turn-weapons-into-art-slideshow/

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Fred Willard, Ed Begley Jr., Michael McKean join Christopher guest's HBO comedy

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Wednesday, September 26, 2012

Report: Framingham Special Education Costs Projected to Increase ...

The Framingham School Committee projects a $34.4 million cost for the Special Education (SPED) programs in the current school year and that price tag is estimated to be about $43 million by 2018 and $55 million by 2023.

Framingham's Finance Committee knowing that the escalating cost of the SPED programs increasingly puts pressure on the annual town budget asked the Framingham Public Schools to prepare a report for the Oct. 16 Special Town Meeting that projects the cost of SPED programs for the next decade.

The Finance Committee also requested the School Committee prepare a plan with Framingham?s state legislators to increase state funding for special education.

?It is a structural deficit in the operating budget,? said Dr. Edward Gotgart, director of business administration for the Framingham Public Schools at Monday night's School Committee meeting. ?SPED is taking a larger portion of dollars in the operating budget.?

From the point of view of Gotgart and Director of Special Education Betsey McKeon, the way to staunch the ever increasing flow of SPED spending would be to increase the schools? operating budget at the same rate as the SPED spending increase and/or pressure the state to increase its funding of mandated SPED programs thus increasing revenue coming to the schools.

When Gotgart ran the numbers out for the next decade he discovered that at the current rates of increased SPED spending and operating budget revenue, SPED would take the school?s entire operating budget by 2013.

?There is no doubt that we will face challenges with SPED,? said Framingham Superintendent of Schools Stacy Scott. ?We will continue to look at ways to increase the influx of funds to the schools.?

According to Gotgart?s figures, the district will spend $34.4 million on SPED programs and support in the current school year.

Five years out, if everything remains the same, SPED spending will be $43.4 million and in 2023 that figure goes to $54.9 million.

By comparison, the school system?s operating budget this year is $98.8 million.

In five years, the operating budget is projected to be $110.7 million and at the end of the 10-year study period $124.1 million.

Gotgart?s figures show an operating budget average increase of 2.3 percent annually while the SPED increase averages 4.8 percent.

In its Town Meeting resolution, the Finance Committee was quick to state, ?The FinCom is not suggesting any decrease in SPED programs or funding. Almost all of these costs are mandated by the state or the federal government and we have little control over them. Moreover, we recognize the importance of these programs in providing much needed services to our students.?

The resolution further stated that Framingham currently has 17 special education out-of-district students that cost the Framingham Public Schools district more than $100,000 each, with one student at a $300,000 a year cost.

Editor's note: Hypothetically, an example of an out-of-district placement could be a student attending the Perkins School for the Blind, due to a severe disability. Framingham Public Schools would be required to not only pay the tuition but also the transportation to and from school. This is just an example.

Source: http://framingham.patch.com/articles/school-committee-report-shows-unabated-increase-in-sped-costs

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Five reasons why your business must use SEO (search engine ...

You can publish the articles of our newsletters on your own web site as long as you follow some simple rules:

  • The articles must not be changed.
  • The links in the articles must remain intact.
  • You must add the following link below the article:

That's all. Improve your web pages with our free content!

Source: http://www.free-seo-news.com/newsletter544.htm

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Design Car Interior: Looking at cheap auto insurance and company ...

With most insurance companies there are things that set them apart from other companies that may appear similar. It is also true that an insurance company is not necessarily a good one just because it claims to offer the lowest rates. You want cheap auto insurance from a reputable insurance company. And you can get that by reviewing a company's ratings. Many agencies, including JD Power and Associates, provide annual lists of the top insurance companies based on several factors.

Coverage Provided

Getting the coverage you need is important. You want sufficient coverage but you do not want to pay for coverage you do not need. An insurance company that always seems to be pushing an upgraded policy on you can be a nuisance. You want your insurance provider to provide information but leave the decision making up to you.

Premium Rates

The competitiveness of the rates is tied with the coverage that is provided. A cheaper auto insurance is not always a better insurance. Low rates are ideal but what you really want is the best value for your money. This means you have to consider the amount of coverage you are getting for the amount of money you spend. You should also take the deductible into consideration. A low rate is great but if your deductible is too high, you may face a financial hardship if you are involved in an accident.

Claims Processing

This factor focuses on the ease at which claims are processed as well as how long it takes for a claim to be approved. Insurance companies that make it easy to submit claims get ranked higher. Most insurance providers now have online claim processing centers. Not only is the claim process faster, but it is more convenient.

Value-Added Services

Complimentary services such as free roadside assistance or free rentals are important to many drivers. These services may not be offered by every insurance provider. Or, you may only get these benefits if you purchase a certain level of coverage.

Customer Service

You want to be able to speak to a company representative when needed. A company that provides 24-hour service may be ideal as long as representatives are knowledgeable and helpful. You might want a company that has a strong online presence with representatives ready to chat with you.

An insurance company's reputation will impact your insurance experience. You can still get cheap auto insurance that includes good coverage by reviewing a company's ratings. To review individual auto insurance companies, check out Standard and Poor's ratings.

Source: http://myrtosgrammaalmanar.blogspot.com/2012/09/looking-at-cheap-auto-insurance-and-company-ratings.html

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Tuesday, September 25, 2012

Clinton: Romney?s '47 percent' remark could haunt him in debates

Clinton (CNN)

Bill Clinton thinks the upcoming presidential debates are crucial for Mitt Romney, and that the Republican candidate's controversial "47 percent" remarks could come back to haunt him.

"I think if he's going to double down on that 47 percent remark, that will cause difficulties," the former president told Piers Morgan on Tuesday in an interview taped at the Clinton Global Initiative. "Because we now know the overwhelming number of those people work and have children, and the reason they don't pay federal income taxes is that median income is as low as it was in 1995 now, and until the current election season, Republicans and Democrats supported both the child tax credit and the earned income tax credit."

In a secretly taped video published by Mother Jones last week, Romney told attendees of a fundraiser that President Barack Obama's core supporters?47 percent of voters, according to the GOP hopeful?"believe they are victims" and "are dependent upon government."

"This is a rejection of basically more than three decades of bipartisan policy to support working families," Clinton said. "It's not a bunch of freeloaders."

[Related: Obama sees 'real problem' with Seahawks/Packers call]

The 42nd president was also asked to weigh in on the controversial call by NFL replacement referees that ended the "Monday Night Football" game between the Seattle Seahawks and the Green Bay Packers.

"I did not think it was a touchdown," Clinton said of the Hail Mary pass. "And I thought the pass was intercepted. I thought the defender hit the ground before there was joint possession. And, yes, it means that we need to get the strike over and get more experienced [referees] in there."

More election video from Yahoo! News:

Source: http://news.yahoo.com/blogs/ticket/bill-clinton-romney-47-percent-190701930--election.html

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Going viral to kill zits

Going viral to kill zits [ Back to EurekAlert! ] Public release date: 25-Sep-2012
[ | E-mail | Share Share ]

Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles Health Sciences

UCLA/Pitt scientists uncover virus with potential to stop pimples in their tracks

Watch out, acne. Doctors soon may have a new weapon against zits: a harmless virus living on our skin that naturally seeks out and kills the bacteria that cause pimples.

The Sept. 25 online edition of the American Society for Microbiology's mBio publishes the findings by scientists at UCLA and the University of Pittsburgh.

"Acne affects millions of people, yet we have few treatments that are both safe and effective," said principal investigator Dr. Robert Modlin, chief of dermatology and professor of microbiology, immunology and molecular genetics at the David Geffen School of Medicine at UCLA. "Harnessing a virus that naturally preys on the bacteria that causes pimples could offer a promising new tool against the physical and emotional scars of severe acne."

The scientists looked at two little microbes that share a big name: Propionibacterium acnes, a bacterium thriving in our pores that can trigger acne; and P. acnes phages, a family of viruses that live on human skin. The viruses are harmless to humans, but programmed to infect and kill the aforementioned P. acnes bacteria.

When P. acnes bacteria aggravate the immune system, it causes the swollen, red bumps associated with acne. Most effective treatments work by reducing the number of P. acnes bacteria on the skin.

"We know that sex hormones, facial oil and the immune system play a role in causing acne, however, a lot of research implicates P. acnes as an important trigger," explained first author Laura Marinelli, a UCLA postdoctoral researcher in Modlin's laboratory. "Sometimes they set off an inflammatory response that contributes to the development of acne."

Using over-the-counter pore cleansing strips from the drugstore, the researchers lifted acne bacteria and the P. acnes viruses from the noses of both pimply and clear-skinned volunteers.

When the team sequenced the bacteriophages' genomes, they discovered that the viruses possess multiple features such as small size, limited diversity and the broad ability to kill their hosts that make them ideal candidates for the development of a new anti-acne therapy.

"Our findings provide valuable insights into acne and the bacterium that causes it," observed corresponding author Graham Hatfull, Eberly Family Professor of Biotechnology, professor of biological sciences at the University of Pittsburgh and a Howard Hughes Medical Institute researcher. "The lack of genetic diversity among the phages that attack the acne bacterium implies that viral-based strategies may help control this distressing skin disorder."

"Phages are programmed to target and kill specific bacteria, so P. acnes phages will attack only P. acnes bacteria, but not others like E. coli," added Marinelli. "This trait suggests that they offer strong potential for targeted therapeutic use."

Acne affects nearly 90 percent of Americans at some point in their lives, yet scientists know little about what causes the disorder and have made narrow progress in developing new strategies for treating it. Dermatologists' arsenal of anti-acne tools -- benzoyl peroxide, antibiotics and Accutane hasn't expanded in decades.

"Antibiotics such as tetracycline are so widely used that many acne strains have developed resistance, and drugs like Accutane, while effective, can produce risky side effects, limiting their use," explained coauthor Dr. Jenny Kim, director of the UCLA Clinic for Acne, Rosacea and Aesthetics. "Acne can dramatically disfigure people and undermine their self-esteem, especially in teens. We can change patients' lives with treatment. It's time we identified a new way to safely treat the common disorder."

The research team plans to isolate the active protein from the P. acnes virus and test whether it is as effective as the whole virus in killing acne bacteria. If laboratory testing proves successful, the researchers will study the compound's safety and effectiveness in combating acne in people.

###

The study was supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21AR060382, R01 AR053542 and F32AR060655) at the National Institutes of Health in Bethesda, Md.

Additional coauthors included Sorel Fitz-Gibbon, Megan Inkeles, Shawn Cokus, Matteo Pellegrini and Jeffrey F. Miller, all of UCLA; former UCLA researchers Clarmyra Hayes and Anya Loncaric, now of the California Institute of Technology and Solta Medical, respectively; and Charles Bowman, Daniel Russell and Deborah Jacobs-Sera of the University of Pittsburgh.

The Clinic for Acne, Rosacea and Aesthetics at the UCLA Division of Dermatology at the David Geffen School of Medicine offers comprehensive care for acne and rosacea, as well as the scarring and discoloration that can result from these conditions. The clinic's goal is to educate the public and help patients develop habits leading to healthy skin. Current research projects include studying the effect of Vitamin-D on immune response to acne, the effect of Omega-3 fatty acids on acne and its treatment, and the use of a mobile device application for acne management. To schedule an appointment, call (310) 825-6911.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Going viral to kill zits [ Back to EurekAlert! ] Public release date: 25-Sep-2012
[ | E-mail | Share Share ]

Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles Health Sciences

UCLA/Pitt scientists uncover virus with potential to stop pimples in their tracks

Watch out, acne. Doctors soon may have a new weapon against zits: a harmless virus living on our skin that naturally seeks out and kills the bacteria that cause pimples.

The Sept. 25 online edition of the American Society for Microbiology's mBio publishes the findings by scientists at UCLA and the University of Pittsburgh.

"Acne affects millions of people, yet we have few treatments that are both safe and effective," said principal investigator Dr. Robert Modlin, chief of dermatology and professor of microbiology, immunology and molecular genetics at the David Geffen School of Medicine at UCLA. "Harnessing a virus that naturally preys on the bacteria that causes pimples could offer a promising new tool against the physical and emotional scars of severe acne."

The scientists looked at two little microbes that share a big name: Propionibacterium acnes, a bacterium thriving in our pores that can trigger acne; and P. acnes phages, a family of viruses that live on human skin. The viruses are harmless to humans, but programmed to infect and kill the aforementioned P. acnes bacteria.

When P. acnes bacteria aggravate the immune system, it causes the swollen, red bumps associated with acne. Most effective treatments work by reducing the number of P. acnes bacteria on the skin.

"We know that sex hormones, facial oil and the immune system play a role in causing acne, however, a lot of research implicates P. acnes as an important trigger," explained first author Laura Marinelli, a UCLA postdoctoral researcher in Modlin's laboratory. "Sometimes they set off an inflammatory response that contributes to the development of acne."

Using over-the-counter pore cleansing strips from the drugstore, the researchers lifted acne bacteria and the P. acnes viruses from the noses of both pimply and clear-skinned volunteers.

When the team sequenced the bacteriophages' genomes, they discovered that the viruses possess multiple features such as small size, limited diversity and the broad ability to kill their hosts that make them ideal candidates for the development of a new anti-acne therapy.

"Our findings provide valuable insights into acne and the bacterium that causes it," observed corresponding author Graham Hatfull, Eberly Family Professor of Biotechnology, professor of biological sciences at the University of Pittsburgh and a Howard Hughes Medical Institute researcher. "The lack of genetic diversity among the phages that attack the acne bacterium implies that viral-based strategies may help control this distressing skin disorder."

"Phages are programmed to target and kill specific bacteria, so P. acnes phages will attack only P. acnes bacteria, but not others like E. coli," added Marinelli. "This trait suggests that they offer strong potential for targeted therapeutic use."

Acne affects nearly 90 percent of Americans at some point in their lives, yet scientists know little about what causes the disorder and have made narrow progress in developing new strategies for treating it. Dermatologists' arsenal of anti-acne tools -- benzoyl peroxide, antibiotics and Accutane hasn't expanded in decades.

"Antibiotics such as tetracycline are so widely used that many acne strains have developed resistance, and drugs like Accutane, while effective, can produce risky side effects, limiting their use," explained coauthor Dr. Jenny Kim, director of the UCLA Clinic for Acne, Rosacea and Aesthetics. "Acne can dramatically disfigure people and undermine their self-esteem, especially in teens. We can change patients' lives with treatment. It's time we identified a new way to safely treat the common disorder."

The research team plans to isolate the active protein from the P. acnes virus and test whether it is as effective as the whole virus in killing acne bacteria. If laboratory testing proves successful, the researchers will study the compound's safety and effectiveness in combating acne in people.

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The study was supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21AR060382, R01 AR053542 and F32AR060655) at the National Institutes of Health in Bethesda, Md.

Additional coauthors included Sorel Fitz-Gibbon, Megan Inkeles, Shawn Cokus, Matteo Pellegrini and Jeffrey F. Miller, all of UCLA; former UCLA researchers Clarmyra Hayes and Anya Loncaric, now of the California Institute of Technology and Solta Medical, respectively; and Charles Bowman, Daniel Russell and Deborah Jacobs-Sera of the University of Pittsburgh.

The Clinic for Acne, Rosacea and Aesthetics at the UCLA Division of Dermatology at the David Geffen School of Medicine offers comprehensive care for acne and rosacea, as well as the scarring and discoloration that can result from these conditions. The clinic's goal is to educate the public and help patients develop habits leading to healthy skin. Current research projects include studying the effect of Vitamin-D on immune response to acne, the effect of Omega-3 fatty acids on acne and its treatment, and the use of a mobile device application for acne management. To schedule an appointment, call (310) 825-6911.


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Source: http://www.eurekalert.org/pub_releases/2012-09/uoc--gvt092012.php

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